ECHE 589 - Machine Learning in Chemical Engineering

Instructor Prof. Shengli Jiang
Term Fall 2026
Time Mondays, Wednesdays, and Fridays, 10:50 – 11:40 AM
Location TBD

Course Overview

This course provides a theoretical and practical introduction to machine learning (ML) methods and their applications in chemical engineering. After an overview of ML algorithms, we will focus on specific applications (e.g., QSPR modeling, molecular simulation, materials design, spectral and image analysis, and process control) to illustrate how ML methods widely adopted in Big Tech are applied to engineering problems. Through topical literature reviews, case studies, and programming-based assignments, students will engage with state-of-the-art methodologies and gain practical experience implementing ML algorithms in an engineering context.

Prerequisites

  • ECHE 456: Computational Methods for Engineering Applications
  • AND one of the following: CSCE 106 (Scientific Applications Programming) or CSCE 145 (Algorithmic Design I)

Schedule

Week Date Topic Materials
1 Week 1 Course Introduction

Overview of machine learning, course structure, and expectations.

Syllabus Slides
2 Week 2 Overview of Machine Learning

Fundamental concepts, branches of ML, and math review.

Lecture Notes Assignment 1
3 Week 3 Regression

Linear and nonlinear regression, and model evaluation.

Lecture Notes Coding Lab
4 Week 4 Feature Engineering and Model Selection

Data representation, feature engineering, and model selection techniques.

Lecture Notes Assignment 2
5 Week 5 Classification

Logistic regression, support vector machines, random forests, and multi-class classification.

Lecture Notes Review Materials
6 Week 6 Neural Networks Fundamentals

Introduction to neural networks, TensorFlow/Keras/PyTorch, and gradient descent.

Lecture Notes Assignment 3
7 Week 7 Unsupervised Learning and Explainable AI

Unsupervised methods, explainable AI, and best practices.

Lecture Notes Coding Lab
8-9 Week 8–9 Molecular-Level Machine Learning

Molecular representations, featurization techniques, and molecular property prediction.

Lecture Notes Coding Lab
10-11 Week 10–11 Product-Level Machine Learning

Bayesian optimization, active learning, and design of experiments.

Lecture Notes Coding Lab
12-13 Week 12–13 Process-Level Machine Learning

Computer vision for process monitoring, fault detection, and diagnosis.

Lecture Notes Coding Lab